Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats
Identifieur interne : 001024 ( Main/Exploration ); précédent : 001023; suivant : 001025Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats
Auteurs : JUNSHI WANG [États-Unis] ; Robert W. Bina [États-Unis] ; Jeffrey C. Wingard [États-Unis] ; Ernest F. Terwilliger [États-Unis] ; Ronald P. Jr Hammer [États-Unis] ; Ella M. Nikulina [États-Unis]Source :
- European journal of neuroscience : (Print) [ 0953-816X ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The nucleus accumbens (NAc) is a critical brain region for the rewarding effects of drugs of abuse. Brain-derived neurotrophic factor (BDNF) can facilitate stress- and drug-induced neuroadaptation in the mesocorticolimbic system. BDNF-containing projections to the NAc originate from the ventral tegmental area (VTA) and the prefrontal cortex, and BDNF release activates tropomyosin-related kinase B (TrkB). In this study, we examined the necessity for BDNF-TrkB signaling in the NAc shell during social defeat stress-induced cross-sensitization to amphetamine. Adeno-associated virus expressing short hairpin RNA directed against TrkB (AAV-shTrkB) was infused bilaterally into the NAc shell to knock down TrkB, whereas AAV-GFP (green fluorescent protein) was used as the control virus. Rats were exposed to intermittent social defeat stress or handling procedures; amphetamine challenge was given at 10 days after the last defeat and locomotor activity was measured. Stressed rats that received the control virus showed cross-sensitization to amphetamine compared with the handled rats. In contrast, NAc TrkB knockdown prevented social defeat stress-induced cross-sensitization. TrkB knockdown in the NAc was found to reduce the level of phospho-extracellular signal-regulated kinase 1 in this region. NAc TrkB knockdown also prevented stress-induced elevation of BDNF and the glutamate receptor type 1 (GluA1) subunit of AMPA receptor in the VTA, as well as AFosB expression in the NAc. These findings indicated that BDNF-TrkB signaling in the NAc shell was required for social defeat stress-induced cross-sensitization. NAc TrkB-BDNF signaling also appeared to be involved in the regulation of GluA1 in the VTA, as well as in the NAc AFosB accumulation that could trigger cross-sensitization after social defeat stress.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000007
- to stream PascalFrancis, to step Corpus: 000015
- to stream PascalFrancis, to step Curation: 000220
- to stream PascalFrancis, to step Checkpoint: 000002
- to stream Main, to step Merge: 001025
- to stream Main, to step Curation: 001024
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats</title>
<author><name sortKey="Junshi Wang" sort="Junshi Wang" uniqKey="Junshi Wang" last="Junshi Wang">JUNSHI WANG</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Neuroscience Program, Arizona State University</s1>
<s2>Tempe, AZ</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bina, Robert W" sort="Bina, Robert W" uniqKey="Bina R" first="Robert W." last="Bina">Robert W. Bina</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wingard, Jeffrey C" sort="Wingard, Jeffrey C" uniqKey="Wingard J" first="Jeffrey C." last="Wingard">Jeffrey C. Wingard</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Beth Israel Deaconess Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terwilliger, Ernest F" sort="Terwilliger, Ernest F" uniqKey="Terwilliger E" first="Ernest F." last="Terwilliger">Ernest F. Terwilliger</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Beth Israel Deaconess Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hammer, Ronald P Jr" sort="Hammer, Ronald P Jr" uniqKey="Hammer R" first="Ronald P. Jr" last="Hammer">Ronald P. Jr Hammer</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Neuroscience Program, Arizona State University</s1>
<s2>Tempe, AZ</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Departments of Pharmacology and Psychiatry, University of Arizona, College of Medicine</s1>
<s2>Phoenix, AZ</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nikulina, Ella M" sort="Nikulina, Ella M" uniqKey="Nikulina E" first="Ella M." last="Nikulina">Ella M. Nikulina</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0138262</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0138262 INIST</idno>
<idno type="RBID">Pascal:14-0138262</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000007</idno>
<idno type="stanalyst">FRANCIS 14-0138262 INIST</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000015</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000220</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000002</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000002</idno>
<idno type="wicri:doubleKey">0953-816X:2014:Junshi Wang:knockdown:of:tropomyosin</idno>
<idno type="wicri:Area/Main/Merge">001025</idno>
<idno type="wicri:Area/Main/Curation">001024</idno>
<idno type="wicri:Area/Main/Exploration">001024</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats</title>
<author><name sortKey="Junshi Wang" sort="Junshi Wang" uniqKey="Junshi Wang" last="Junshi Wang">JUNSHI WANG</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Neuroscience Program, Arizona State University</s1>
<s2>Tempe, AZ</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bina, Robert W" sort="Bina, Robert W" uniqKey="Bina R" first="Robert W." last="Bina">Robert W. Bina</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wingard, Jeffrey C" sort="Wingard, Jeffrey C" uniqKey="Wingard J" first="Jeffrey C." last="Wingard">Jeffrey C. Wingard</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Beth Israel Deaconess Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terwilliger, Ernest F" sort="Terwilliger, Ernest F" uniqKey="Terwilliger E" first="Ernest F." last="Terwilliger">Ernest F. Terwilliger</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Beth Israel Deaconess Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hammer, Ronald P Jr" sort="Hammer, Ronald P Jr" uniqKey="Hammer R" first="Ronald P. Jr" last="Hammer">Ronald P. Jr Hammer</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Neuroscience Program, Arizona State University</s1>
<s2>Tempe, AZ</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Departments of Pharmacology and Psychiatry, University of Arizona, College of Medicine</s1>
<s2>Phoenix, AZ</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nikulina, Ella M" sort="Nikulina, Ella M" uniqKey="Nikulina E" first="Ella M." last="Nikulina">Ella M. Nikulina</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Medical Sciences, University of Arizona, College of Medicine, 425 N 5th Street</s1>
<s2>Phoenix, AZ, 85004</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ, 85004</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">European journal of neuroscience : (Print)</title>
<title level="j" type="abbreviated">Eur. j. neurosci. : (Print)</title>
<idno type="ISSN">0953-816X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">European journal of neuroscience : (Print)</title>
<title level="j" type="abbreviated">Eur. j. neurosci. : (Print)</title>
<idno type="ISSN">0953-816X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amfetamine</term>
<term>Animal</term>
<term>Biological receptor</term>
<term>Brain derived neurotrophic factor</term>
<term>Nucleus accumbens</term>
<term>Rat</term>
<term>Stress</term>
<term>Tropomyosin kinase</term>
<term>Ventral tegmental area</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tropomyosin kinase</term>
<term>Récepteur biologique</term>
<term>Noyau accumbens</term>
<term>Stress</term>
<term>Amfétamine</term>
<term>Facteur BDNF</term>
<term>Aire tegmentaire ventrale</term>
<term>Rat</term>
<term>Animal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The nucleus accumbens (NAc) is a critical brain region for the rewarding effects of drugs of abuse. Brain-derived neurotrophic factor (BDNF) can facilitate stress- and drug-induced neuroadaptation in the mesocorticolimbic system. BDNF-containing projections to the NAc originate from the ventral tegmental area (VTA) and the prefrontal cortex, and BDNF release activates tropomyosin-related kinase B (TrkB). In this study, we examined the necessity for BDNF-TrkB signaling in the NAc shell during social defeat stress-induced cross-sensitization to amphetamine. Adeno-associated virus expressing short hairpin RNA directed against TrkB (AAV-shTrkB) was infused bilaterally into the NAc shell to knock down TrkB, whereas AAV-GFP (green fluorescent protein) was used as the control virus. Rats were exposed to intermittent social defeat stress or handling procedures; amphetamine challenge was given at 10 days after the last defeat and locomotor activity was measured. Stressed rats that received the control virus showed cross-sensitization to amphetamine compared with the handled rats. In contrast, NAc TrkB knockdown prevented social defeat stress-induced cross-sensitization. TrkB knockdown in the NAc was found to reduce the level of phospho-extracellular signal-regulated kinase 1 in this region. NAc TrkB knockdown also prevented stress-induced elevation of BDNF and the glutamate receptor type 1 (GluA1) subunit of AMPA receptor in the VTA, as well as AFosB expression in the NAc. These findings indicated that BDNF-TrkB signaling in the NAc shell was required for social defeat stress-induced cross-sensitization. NAc TrkB-BDNF signaling also appeared to be involved in the regulation of GluA1 in the VTA, as well as in the NAc AFosB accumulation that could trigger cross-sensitization after social defeat stress.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Arizona"><name sortKey="Junshi Wang" sort="Junshi Wang" uniqKey="Junshi Wang" last="Junshi Wang">JUNSHI WANG</name>
</region>
<name sortKey="Bina, Robert W" sort="Bina, Robert W" uniqKey="Bina R" first="Robert W." last="Bina">Robert W. Bina</name>
<name sortKey="Hammer, Ronald P Jr" sort="Hammer, Ronald P Jr" uniqKey="Hammer R" first="Ronald P. Jr" last="Hammer">Ronald P. Jr Hammer</name>
<name sortKey="Hammer, Ronald P Jr" sort="Hammer, Ronald P Jr" uniqKey="Hammer R" first="Ronald P. Jr" last="Hammer">Ronald P. Jr Hammer</name>
<name sortKey="Hammer, Ronald P Jr" sort="Hammer, Ronald P Jr" uniqKey="Hammer R" first="Ronald P. Jr" last="Hammer">Ronald P. Jr Hammer</name>
<name sortKey="Nikulina, Ella M" sort="Nikulina, Ella M" uniqKey="Nikulina E" first="Ella M." last="Nikulina">Ella M. Nikulina</name>
<name sortKey="Terwilliger, Ernest F" sort="Terwilliger, Ernest F" uniqKey="Terwilliger E" first="Ernest F." last="Terwilliger">Ernest F. Terwilliger</name>
<name sortKey="Wingard, Jeffrey C" sort="Wingard, Jeffrey C" uniqKey="Wingard J" first="Jeffrey C." last="Wingard">Jeffrey C. Wingard</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001024 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001024 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= StressCovidV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:14-0138262 |texte= Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats }}
This area was generated with Dilib version V0.6.33. |